Food supplements should not be used as a substitute for a varied diet. If you are taking prescribed medication, have any medical condition or are pregnant or breast-feeding please consult your healthcare practitioner before taking food supplements. Kang, H. J., Jo, C., Kwon, J. H., Son, J. H., An, B. J., and Byun, M. W. (2006). Antioxidant and cancer cell proliferation inhibition effect of citrus pectin-oligosaccharide prepared by irradiation. J. Med. Food 9, 313–320. doi: 10.1089/jmf.2006.9.313 Locati M, Curtale G, Mantovani A. Diversity, mechanisms, and significance of macrophage plasticity. Annu Rev Pathol. 2020;15:123–47. Hossein G, Halvaei S, Heidarian Y, Dehghani-Ghobadi Z, Hassani M, Hosseini H, et al. Pectasol-C modified citrus pectin targets galectin-3-induced STAT3 activation and synergize paclitaxel cytotoxic effect on ovarian cancer spheroids. Cancer Med. 2019;8:4315–29. Chauhan, D., Li, G., Podar, K., Hideshima, T., Neri, P., He, D., et al. (2005). A novel carbohydrate-based therapeutic GCS-100 overcomes bortezomib resistance and enhances dexamethasone-induced apoptosis in multiple myeloma cells. Cancer Res. 65, 8350–8358. doi: 10.1158/0008-5472.CAN-05-0163

PectaSol-C (Modified Citrus Pectin) 454g – ecoNugenics

Olano-Martin, E., Gibson, G. R., and Rastell, R. A. (2002). Comparison of the in vitro bifidogenic properties of pectins and pectic-oligosaccharides. J. Appl. Microbiol. 93, 505–511. doi: 10.1046/j.1365-2672.2002.01719.x The number of fecal lactobacilli in the MCP alginate probiotic-treated mice significantly increased Watanabe, K., Reddy, B. S., Weisburger, J. H., and Kritchevsky, D. (1979). Effect of dietary alfalfa, pectin, and wheat bran on azoxymethane-or methylnitrosourea-induced colon carcinogenesis in F344 rats. J. Natl. Cancer Inst. 63, 141–145. Platt, D., and Raz, A. (1992). Modulation of the lung colonization of B16-F1 melanoma cells by citrus pectin. J. Natl. Cancer Inst. 84, 438–442. doi: 10.1093/jnci/84.6.438 PectaSol-C Modified Citrus Pectin, Potassium, Sodium, Dietary Fiber, Vegetable capsule (natural vegetable cellulose, water), stearic acid, magnesium stearate, microcrystalline cellulose, silicon dioxide.Glinsky, V. V., and Raz, A. (2009). Modified citrus pectin anti-metastatic properties: one bullet, multiple targets. Carbohydr. Res. 344, 1788–1791. doi: 10.1016/j.carres.2008.08.038 MCP effectively inhibits the growth and metastasis of gastrointestinal cancer cells, partly by down-regulating Bcl-xL and Cyclin B to promote apoptosis and suppress EMT Johnson, K. D., Glinskii, O. V., Mossine, V. V., Turk, J. R., Mawhinney, T. P., Anthony, D. C., et al. (2007). Galectin-3 as a potential therapeutic target in tumors arising from malignant endothelia. Neoplasia 9, 662–670. doi: 10.1593/neo.07433 Emran TB, Islam F, Mitra S, Paul S, Nath N, Khan Z, Das R, Chandran D, Sharma R, Lima CMG, Awadh AAA, Almazni IA, Alhasaniah AH, Guiné RPF. Emran TB, et al. Molecules. 2022 Oct 31;27(21):7405. doi: 10.3390/molecules27217405. Molecules. 2022. PMID: 36364232 Free PMC article. Review. Cannarile MA, Weisser M, Jacob W, Jegg AM, Ries CH, Rüttinger D. Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy. J Immunother Cancer. 2017;5:53.

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Liners, F., Letesson, J. J., Didembourg, C., and Van Cutsem, P. (1989). Monoclonal antibodies against pectin: recognition of a conformation induced by calcium. Plant Physiol. 91, 1419–1424. doi: 10.1104/pp.91.4.1419 Glinsky VV, Raz A. Modified citrus pectin anti-metastatic properties: one bullet, multiple targets. Carbohydr Res. 2009;344:1788–91. In experimental models of mild kidney damage, the increase in renal Gal-3 expression paralleled with renal fibrosis and inflammation, while these alterations prevented with MCP To demonstrate the efficacy of PectaSol-C modified citrus pectin (MCP) on prostate cancer in vitro. MCP inhibited the survival of TAM in hypoxia by reducing glucose uptake via downregulation of GLUT-1 in vitroEliaz, I., Hotchkiss, A. T., Fishman, M. L., and Rode, D. (2006). The effect of modified citrus pectin on urinary excretion of toxic elements. Phytother. Res. 20, 859–864. doi: 10.1002/ptr.1953 Kolar, S., Barhoumi, R., Jones, C. K., Wesley, J., Lupton, J. R., Fan, Y. Y., et al. (2011). Interactive effects of fatty acid and butyrate-induced mitochondrial Ca(2)(+) loading and apoptosis in colonocytes. Cancer 117, 5294–5303. doi: 10.1002/cncr.26205

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After polarized into M2 phenotype, the cells were treated with serial concentrations of MCP (in PBS) for 24 h. The lactate acid contents were determined using Lactic Acid kit (NJJCBIO, Wuhan, China) following the manufacturer’s instructions. Cells were collected and the number of cells was counted by cell counter. Quantitative real-time PCR (qRT-PCR) In vitro angiogenesis or vascular mimicry assay was performed as previously described [ 10]. In brief, MM231 cells or HUVECs were added into 96-well plate precoated with 100 μL Matrigel and cultured with 100 μL CM for 6 h at 37 °C. The total branching length of tube, which represent the tube forming ability of cells, was calculated by ImageJ software. Transwell co-culture system Attari, F., Sepehri, H., Delphi, L., and Goliaei, B. (2009). Apoptotic and necrotic effects of pectic acid on rat pituitary GH3/B6 tumor cells. Iran Biomed J. 13, 229–236. Cytotoxicity analysis of PectaSol-C was performed by MTT assay, as were parallel studies with the former brand version of MCP called PectaSol. Apoptosis and inhibition of cell growth were investigated by Western blotting.Prata C, Maraldi T, Fiorentini D, Zambonin L, Hakim G, Landi L. Nox-generated ROS modulate glucose uptake in a leukaemic cell line. Free Radic Res. 2008;42:405–14.