When taken by mouth: Hyaluronic acid is likely safe when used appropriately. Allergic reactions might occur but are rare. The serum promises softer, firmer skin, and we did experience those benefits. In fact, plumping was one of the biggest benefits we noticed. We saw a reduction in fine lines and wrinkles but an increase in fullness. After using this serum regularly, our skin looked healthier and more glowy. Dermatologists generally love CeraVe. Both Dr. Salyards and Dr. Brauer give CeraVe hyaluronic acid serum glowing recommendations for its effective but thoughtful formula. “You can’t go wrong with CeraVe products,” says Dr. Salyards, adding that they’re affordable, accessible, and suitable for those with sensitive skin and other skin issues that can make it harder to find the right skin care routine.

Breast-feeding: There isn't enough reliable information to know if hyaluronic acid is safe to use when breast-feeding. It's not clear if it's excreted in breast milk and what effect that might have on an infant. Stay on the safe side and avoid use. Palmieri B, Merighi A, Corbascio D, Rottigni V, Fistetto G, Esposito A. Fixed combination of hyaluronic acid and chondroitin-sulphate oral formulation in a randomized double blind, placebo controlled study for the treatment of symptoms in patients with non-erosive gastroesophageal reflux. Eur Rev Med Pharmacol Sci 2013;17(24):3272-8. View abstract. You may have heard a lot in recent years about hyaluronic acid (HA), the wonder ingredient that has found its way into seemingly everything from face creams and foundations to shampoos and eyelash treatments. A brilliant hydrator, hyaluronic acid helps to plump up and retain moisture in the skin, smoothing away fine lines and wrinkles and giving skin a younger, fresher feel. It’s true that hyaluronic acid is especially beneficial for those who lean on the dry side, but dermatologists want you to know that this hydrator is great for all skin types. One of its best attributes is its ability to strengthen the skin’s natural barrier by reducing trans-epidermal water loss, says Jill Salyards, DO, a board-certified dermatologist with a private practice in Knoxville, Tennessee. The results will be most visible on those with dryness or loss of elasticity, but it can certainly rejuvenate any and all skin. You can find this superstar ingredient in all types of skin care products, but a hyaluronic acid serum is a great choice because serums tend to be watery and more potent. Hyaluronic acid is a naturally occurring substance made by our skin cells that supports our skin's barrier function, explains Greenfield. It’s a humectant that holds up to 1,000 times its weight in water, essentially drawing in and binding moisture to the skin, softening and hydrating it without being overly heavy. “When applying hyaluronic acid to our skin topically [through a serum], we’re giving our skin what is needed to maintain its barrier function and keep us healthy,” she says.CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Ingredients to Avoid: Anything to avoid? Aside from potential irritants or triggers, try not to layer multiple products containing hyaluronic acid. You only want one source of hyaluronic acid in your routine to avoid irritation from overexposure, Dr. Salyards says. Formulated with mature skin in mind, Dr. Dennis Gross’s Hyaluronic Marine Booster contains moisturizing watermelon extract and centella asiatica (aka cica) to smooth the appearance of fine lines. We like that this multifunctional serum can be applied all over the face or on dry patches as needed. Do note that the water-like consistency is runny, so consider using the dropper applicator to dispense the product directly on the skin to avoid waste. Altman RD, Moskowitz R. Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial. Hyalgan Study Group. J Rheumatol 1998;25:2203-12. View abstract.

Peter Thomas Roth Water Drench Hyaluronic Glow Serum: It’s impossible to discuss products for dry skin without mentioning the Water Drench collection from Peter Thomas Roth. It gave our skin a nice glow and even improved some wrinkles, but we couldn’t tell a huge difference in the moisture levels of our skin. For a serum that’s supposed to increase moisture, we were surprised it didn’t live up to the hype, but it could work nicely for those looking for an anti-aging serum. Although hyaluronic acid works for all skin types, board-certified dermatologist Dr. Nava Greenfield recommends considering your skin type to find the one that suits your needs best. For example, if you have oily skin, she explains, you’ll want to look for a water-based product. We recommend the La Roche-Posay Hyalu B5 Pure Hyaluronic Acid Serum for this. If you have dry skin, she says, try an oil- or cream-based serum for optimal hydration. The Peter Thomas Roth Water Drench Hyaluronic Glow Serum is one of our favorites for very dry skin. Alcohol-Free Formulations According to dermatologists, hyaluronic acid is a gentle active ingredient that can be paired with many other active ingredients. You can use hyaluronic acid in the same routine as ingredients like retinol, vitamin C, and others. However, you should try to avoid layering multiple products that each contain hyaluronic acid. In doing so, you could cause some irritation from using too much of the same ingredient. Wei M, Zou Y, Duan F, et al. Efficacy of Long-term Use of 0.3% Sodium Hyaluronate Eye Drops for Traumatic Corneal Abrasion: A Randomized Controlled, Pilot Trial. Cornea 2021;40(10):1248-1252. View abstract. Ana Mansouri, MD, is a cosmetic doctor at Kat & Co Aesthetics based in the UK who specializes in injectables and aesthetics.Claire Wolinsky, MD, is a board-certified New York-based dermatologist. She specializes in facial rejuvenation. Pellegatta G, Mangiavillano B, Semeraro R, et al. The effect of hyaluronic acid and chondroitin sulphate-based medical device combined with acid suppression in the treatment of atypical symptoms in gastroesophageal reflux disease. J Clin Med 2022;11(7):1890. View abstract. Torretta S, Marchisio P, Rinaldi V, et al. Topical administration of hyaluronic acid in children with recurrent or chronic middle ear inflammations. Int J Immunopathol Pharmacol. 2016;29(3):438-42. You should see smoother, less lined, more moisturised skin almost instantly and you will notice your skin feels softer, too," explains Paula, saying everything we want to hear. "Over time, fine lines and wrinkles will become less apparent, skin will maintain a youthful plump and supple feel, and be much less prone to showing signs of dryness and dehydration. Used as part of a skincare routine that includes daily sun protection, products with hyaluronic acid naturally restore the skin’s ability to look and act younger. It isn’t a miracle cure, but it’s a beautiful ingredient for maintaining your skin." Are there any downsides to using hyaluronic acid? Aragona P, Benítez-Del-Castillo JM, Coroneo MT, et al. Safety and efficacy of a preservative-free artificial tear containing carboxymethylcellulose and hyaluronic acid for dry eye disease: A randomized, controlled, multicenter 3-month study. Clin Ophthalmol. 2020;14:2951-2963. View abstract.

Liu YR, Liu B, Yang BP, Lan Y, Chi YG. Efficacy of hyaluronic acid on the prevention of intrauterine adhesion and the improvement of fertility: a meta-analysis of randomized trials. Complement Ther Clin Pract 2022;47:101575. View abstract. Our 5ml sachets contain a potent 17mg of pure fermentation-based mid-molecular weight hyaluronic acid, carefully complemented with 12mg (15% RDI) of vitamin C. This dynamic duo works harmoniously to replenish your body’s natural supply. As a naturally-occurring substance, hyaluronic acid is renowned for its safety and ease of integration into your daily life, becoming an ally in your quest for lasting beauty. SUITABLE FOR

Duperre J, Grenier B, Lemire J, Mihalovits H, Sebag M, Lambert J. Effect of timolol vs. acetazolamide on sodium hyaluronate-induced rise in intraocular pressure after cataract surgery. Can J Ophthalmol 1994;29:182-6. View abstract. Petrella RJ, DiSilvestro MD, Hildebrand C. Effects of hyaluronate sodium on pain and physical functioning in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled clinical trial. Arch Intern Med 2002;162:292-8. View abstract. A facial serum is the most potent way to give your skin a concentrated burst of any skincare ingredient, and a serum primarily containing hyaluronic acid is an efficient way to infuse the skin with this plumping and hydrating wonder-stuff. If your goal is softer, firmer, fresher skin, adding a layer of HA serum to your skincare routine can really make a difference to your skin’s hydration levels and overall texture.

If you have any questions or concerns, please don't hesitate to reach out to our friendly customer service team. GUARANTEEDUthman, I., Raynauld, J. P., and Haraoui, B. Intra-articular therapy in osteoarthritis. Postgrad.Med J 2003;79(934):449-453. View abstract. Kramer K, Senninger N, Herbst H, Probst W. Effective prevention of adhesions with hyaluronate. Arch Surg 2002;137:278-82. View abstract. Mozzanica F, Preti A, Gera R, et al. Double-blind, randomised controlled trial on the efficacy of saline nasal irrigation with sodium hyaluronate after endoscopic sinus surgery. J Laryngol Otol. 2019;133(4):300-308. View abstract. Percival SP. Complications from use of sodium hyaluronate (Healonid) in anterior segment surgery. Br J Ophthalmol 1982;66:714-6. View abstract. Boccalari E, Tadakamadla SK, Occhipinti C, Lanteri V, Maspero C. Evaluation of the effectiveness of a novel mouth rinse containing hyaluronic acid and hydrogen peroxide on gingivitis: a randomized pilot controlled trial. Clin Exp Dent Res 2022;8(3):673-9. View abstract.