Berberine appears to activate AMP-activated protein kinase, which can help regulate how the body uses blood sugar. Researchers believe this activation can help treat diabetes and related health issues, such as obesity and high cholesterol. In some situations, berberine may cause digestive side effects, such as diarrhea, constipation, flatulence, and stomach pain ( 10). However, it’s risky to take a prescription medication and a supplement that are supposed to do the same thing (i.e. lower blood sugar) at the same time, since whether these drugs interact, or inhibit each others’ mechanism of action is unknown. A: Berberine primarily acts on your body’s metabolic environment, helping to prevent the stresses of a poor diet and the stresses of being overweight or obese from causing increases in your blood lipids and blood cholesterol.

Berberine is a promising supplement - Mayo Clinic Press

This supplement also uses a targeted delivery system, and the serving size is only one capsule, which is always appreciated.

The Gastrointestinal Microbiota (GM)

Berberine also appears to inhibit the growth of fat cells at the molecular level, which could help promote weight loss ( 16).

berberine supplements of 2022 - Body Nutrition Ranking the best berberine supplements of 2022 - Body Nutrition

As berberine is a more natural way to support blood glucose, many are now searching for the best berberine supplements—and we’ve got you covered. The team behind another study observed that berberine may activate brown adipose tissue. This tissue helps the body turn food into body heat, and increased activation may help treat obesity and metabolic syndrome.

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Wei W, Zhao H, Wang A, et al. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome. Eur J Endocrinol. 2012;166:99-105. doi:10.1530/EJE-11-0616 Improves Insulin Resistance. In a 2021 meta-analysis, researchers compiled data from 46 trials looking at the effects of berberine on people with prediabetes or type 2 diabetes. Berberine treatment was found to improve insulin resistance—a state when the body stops responding to insulin, the hormone that shuttles glucose from the blood into cells.

Berberine Tea? The Benefits, Side Effects, and More What is Berberine Tea? The Benefits, Side Effects, and More

Sun R, Yang N, Kong B, et al. Orally administered berberine modulates hepatic lipid metabolism by altering microbial bile acid metabolism and the intestinal fxr signaling pathway. Mol Pharmacol. 2017;91:110-122. doi:10.1124/mol.116.106617The first recorded use of berberine was in ancient China at around 3000 BCE, and it was described in the ‘The Divine Farmers Materia Medica’ which is one of the founding books used in Chinese medicine.

Berberine Supplement UK | 98.5% Purity Tested | 5* Trust Pilot Berberine Supplement UK | 98.5% Purity Tested | 5* Trust Pilot

Tabeshpour, J., et al. (2017). A review of the effects of Berberis vulgaris and its major component, berberine, in metabolic syndrome. Although berberine comes from different plants (goldenseal, barberry, Oregon grape, etc.), they aren’t thought to be more or less effective depending on which plant they come from. Although the bitter taste isn’t great, this berberine liquid extract (which comes from dried barberry root) can get the job done—and if it’s too unpleasant for you, adding it to a bit of fruit juice can lessen the bitter load. According to an older review of 14 studies, berberine may be as effective as certain oral diabetes drugs, including metformin, glipizide, and rosiglitazone ( 12).

Have you heard that there is a plant-based medicine that can be as effective as pharmaceuticals? When you think of herbal medicine, berberine may not be the first name that springs to mind, but this plant-derived extract has been proven to be a potent medicinal compound. It has been tested in human models too, not just in the laboratory setting which can sometimes be the case. A: Some basic biological research conducted in cells on Petri dishes suggests that certain kinds of cells (mostly tumor cells, or ovary cells) may reduce their expression of testosterone and other androgens, but in terms of effects on your body overall, there’s no evidence that berberine will either lower or boost your testosterone levels . Berberine’s specialized uses informed our ranking procedure: since there are several clinical trials on using berberine, we were able to compare the delivery mechanism, dosage, and purity of the products we considered to the gold standard of what’s used in scientific research. Specifically, we looked for: Jiang XW, Zhang Y, Zhu YL, et al. Effects of berberine gelatin on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial in a Chinese cohort. Oral Med. 2013;115:212-7. doi:10.1016/j.oooo.2012.09.009