Acetyl-CoA carboxylase 1 (ACC 1) -converts acetyl CoA to malonyl CoA, which is a significant step in lipid synthesis Also called vitamin H or vitamin B7, it’s important for eye, hair, skin, and brain function. It may also support liver function ( 1, 2).

Biotin Deficiency - StatPearls - NCBI Bookshelf

Vitamin C acts as an antioxidant in our bodies and plays an important role in our skin health. Skin contains vitamin C, which supports collagen synthesis and helps protect against damage from UV-rays. As such, you may have seen vitamin C-infused serums or moisturizers in the beauty world. Ongoing research suggests topical vitamin C can reduce hyperpigmentation and tissue inflammation; however, it’s best to talk with a dermatologist to determine if this type of vitamin C is appropriate for you. Biotin and other B vitamins are water-soluble, so it’s hard to overdose on them. “If you take in more biotin than you need, your body doesn’t store it,” Barth explains. “You naturally get rid of excess biotin and other B vitamins when you urinate.” Alopecia is a well-known sign of established zinc deficiency with hair regrowth occurring with zinc supplementation [ 122], [ 123]. Data correlating zinc levels with TE and AGA are, on the other hand, not homogeneous. A retrospective cross-sectional study of 115 subjects diagnosed with TE (acute and chronic) found that 9.6% of subjects had zinc deficiency [ 48]. Another study comparing 312 subjects with hair loss (including AA, MPHL, FPHL, and TE) with 32 controls showed low levels of zinc in patients with AA and TE. These authors recommended zinc replacement if levels were < 70µg/dL [ 124]. However, this finding was not confirmed by a recent study of 40 patients with CTE, with 30 healthy subjects as controls, with the authors finding no difference in zinc levels between the affected and control patients. [ 125]. Get Diet and Fitness Tips In Your Inbox Eat better and exercise smarter. Sign up for the Food & Fitness newsletter.Published data on AA suggest that vitamin D, due to its immunomodulatory effect, may be involved in AA [ 66, 67]. Lee et al. conducted a systematic review and meta-analysis of observational studies on the prevalence of vitamin D deficiency and/or serum vitamin D levels and AA [ 68]. These authors analyzed a total of 14 studies that involved 1255 patients with AA and 784 control patients without AA. The mean serum 25-hydroxyvitamin D [25(OH)D] level in patients with AA was significantly lower than that in the non-AA control group, by 8.52ng/dL (95% confidence interval −11.53 to −5.50ng/dL). Vitamin D deficiency was also highly prevalent in patients with AA, leading the authors to suggest that the vitamin D level has to be measured in patients with AA. These results also suggest that vitamin D supplements or topical vitamin D analogues should be considered for patients with AA and vitamin D deficiency. However, the meta-analysis did not find any clear correlations between extent of hair loss and serum 25-hydroxyvitamin D level [ 68]. Gowda et al. conducted a cross-sectional study to evaluate the prevalence of nutritional deficiencies in 100 Indian patients with hair loss. Their results indicate that a relatively higher proportion of participants with TE (20.37%) had iron deficiency compared to those with FPHL (16.67%) and male pattern hair loss (MPHL) (2.94%) ( p=0.069). Furthermore, transferrin saturation and ferritin levels were lower in patients with FPHL (41.67%) and TE (40.74%) than in patients with MPHL (11.76%) [ 109]. Iron deficiencies were found to be related to gender rather than to type of hair loss. Bananas. One serving (half a cup) of banana has 0.2 micrograms of biotin. Bananas also have vitamin B6, vitamin C, and the minerals manganese, potassium, and magnesium.

Biotin Benefits: What the Experts Have to Say – Cleveland Clinic

They’re most often eaten on their own, but you can also add them to smoothies, spread nut butter on them, or freeze them to make nondairy ice cream. SUMMARYOne small banana (105 grams) also provides approximately 0.2 mcg of biotin, or 1% of the DV ( 4, 8). As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, Sweet potatoes can be baked or microwaved until soft. You can also peel, boil, and mash them or add them to homemade veggie burger patties. SUMMARY

The Role of Vitamins and Minerals in Hair Loss: A Review

A recent review article evaluating biotin and its effect on human hair found 18 reported cases of biotin use on hair and nail. In ten of these 18 cases there was a genetic cause of biotin deficiency; the remaining eight patients had alopecia that was improved after they had taken biotin supplementation. There were three cases of uncombable hair syndrome, three cases of brittle nail syndrome, one case of alopecia due to valproic acid intake, and one case of an infant on a biotin-free dietary supplement. All of these 18 patients had underlying causes of biotin deficiency and, once treated with biotin supplement, showed clinical improvement in a variable time period [ 35]. Other useful ingredients may be included in certain biotin supplements, whether it is to boost absorption, effectiveness or to offer additional nutritional support. Coconut oil regularly features in combination with biotin for better nutrient absorption. Prolonged use of oral antibioticsmay also lead to biotin deficiency. The most likely underlying mechanism is the inhibition of intestinal flora, leading to reduced biotin production. Another possibleexplanation isthe antibiotic-driven overgrowth of biotin-consuming bacteria. [12] If you're trying to grow your hair fast, you've probably heard about biotin. An over-the-counter vitamin that's used in everything from hair, skin and nails tablets to biotin-rich shampoos, it's one of the most searched for supplements out there.There are a couple different ways to reap the benefits of biotin. Believe it or not, you may be already getting a decent dose without knowing it. It’s also a good source of biotin. Just 1/2 cup (45 gram) of raw, chopped broccoli contains 0.4 mcg, or 1% of the DV ( 4, 8). Biotin is probably the most well-known over-the-counter (OTC) supplement for beauty needs. Biotin is part of the B complex that helps our bodies convert food into energy and metabolize fats and proteins. If you don’t get enough biotin, you may see thinning of hair, scaly skin, and brittle nails. As observed in swine, initial clinical symptoms of acquired biotin deficiency include gradual onset of hair loss, dry skin, and lesions on the feet and legs after six months of biotin deficiency. [4] After nine months, the clinical picture resembles a characteristic cutaneous lesion of biotin deficiency. After 3 to 4 weeks of having a raw egg diet in adult humans, desquamative dermatitis was observed. After five weeks, anorexia, lethargy, and hyperaesthesia developed. Administration of biotin relieved symptoms in 5 days. Infants may initially show mild scaly erythema and dermatitis on the face, particularly malar prominences, which may resemble dermatitis rash due to soaps.Holocarboxylase synthetase deficiencycan present very early in fetal life in the form of abnormal CNS findings and intrauterine growth retardation. [29] So don’t assume taking biotin supplements will cure hair, skin or nail problems. “If you notice sudden changes in your hair, skin or nails, see your provider,” says Barth. “Don’t self-treat with biotin supplements without knowing the cause.” How much biotin do you need?

Biotin and Zinc: What You Need to Know - Particle

In 2017, Thompson et al. reviewed five other studies investigating the relationship between AA and iron [ 55]. None of these studies supported an association between AA and iron deficiency [ 27, 44, 111– 113].

Top 5 Biotin Supplements

Certain organ meats, especially liver, are high in biotin. This makes sense biologically, as most of your body’s biotin is stored in your liver. Research shows that both biotin and zinc contribute to healthy hair and skin. A potent supplement can give your body a boost of these beneficial nutrients. The amount of biotin you need daily depends on your age and gender. The FDA says adults need 30 micrograms daily. If you're nursing, you need 35 micrograms every day. Biotin deficiency leads to variable clinical presentations, mainly neurological and dermal abnormalities. Biotinidase deficiency is the commonest etiology; in many countries, including the US, screening for biotinidase deficiency is a part of the newborn screening program. Therefore the condition is identified in many individuals before symptoms develop. History includes recognizing risk factors for biotin deficiency, such as history related to gastrointestinal disease or inflammatory bowel disease. Any history of drug intake that interferes with biotin metabolism or uptake is significant, e.g., antiepileptics, antibiotics, or isotretinoin. Dermal abnormalities in biotin deficiency are due to impaired fatty acid metabolism. These include hair loss (alopecia) and periorificial dermatitis; scaly, red rash around the orifices, i.e., eyes, nose, and mouth (also called “biotin-deficient face”). The rash is similar to that of zinc deficiency. Patients may also develop conjunctivitis and skin infections. Nuts and seeds have biotin, but how much you get depends. For instance, a one-fourth cup of roasted almonds has 1.5 micrograms, but just six walnut halves have 9.5 micrograms. A one-fourth cup of roasted sunflower seeds has 2.6 micrograms of biotin, more than the amount present in any other seed.