Solgar Inositol 500 mg Vegetable Capsules - Vitamin B8 - Vegan, Vegetarian, Kosher, 50 Count (Pack of 1)

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When applied to the skin: There isn't enough reliable information to know if inositol is safe or what the side effects might be. Pregnancy: Inositol is possibly safe when taken by mouth, short-term. Doses of up to 4000 mg of myo-inositol daily have been used with apparent safety. Lepore E, Lauretta R, Bianchini M, Mormando M, Di Lorenzo C, Unfer V. Inositols Depletion and Resistance: Principal Mechanisms and Therapeutic Strategies. Int J Mol Sci. 2021 Jun 24;22(13):6796. doi:10.3390/ijms22136796. Motuhifonua SK, Lin L, Alsweiler J, Crawford TJ, Crowther CA Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes. Cochrane Database Syst Rev. (2023-Feb-15) Donne, M., et al., Effects of three treatment modalities (diet, myoinositol or myoinositol associated with D-chiro-inositol) on clinical and body composition outcomes in women with polycystic ovary syndrome. Eur Rev Med Pharmacol Sci, 2019. 23(5): p. 2293-2301.

Wei J, Yan J, Yang H Inositol Nutritional Supplementation for the Prevention of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. (2022-Jul-09)In a double blind trial published in 2011 in the European Review for Medical and Pharmacological Sciences, researchers compared the effects of supplementation with 2g myo-inositol and 200 mcg folic acid compared to 200 mcg folic acid taken twice daily for 3 months in women with PCOS undergoing IVF and ovulation induction. At the end of the treatment, in the group taking myo-inositol, both the number and quality of oocytes (immature egg cells) was greatly improved. The authors concluded, “these data suggest that myo-inositol may be useful in the treatment of PCOS patients undergoing ovulation induction, both for its insulin sensitizing activity, and its role in oocyte maturation.” 17 Additional research has found myo-inositol to be useful for improving oocyte quality, ovulation and pregnancy outcomes. 18-22 Croze ML, Soulage CO. Potential role and therapeutic interests of myo-inositol in metabolic diseases. Biochimie 2013 95 1811–1827. 10.1016/j.biochi.2013.05.011 In 2003, The Rotterdam consensus defined the diagnostic criteria of PCOS as the presence of any two of the following three features: hyperandrogenism (clinical or biochemical), ovulatory dysfunction (often manifested by menstrual irregularities), and polycystic ovarian morphology (PCOM) by ultrasound. The Rotterdam criteria remains the most used diagnostic criteria for both individual diagnosis and research and yet is still generally accepted to have limitations.

Take my PCOS inositol quiz to find out if a 40:1 ratio is best for you. 10. Ovasitol is the Best 40:1 Ratio Brand for PCOS Nerve pain in people with diabetes ( diabetic neuropathy). Taking inositol by mouth doesn't seem to improve the symptoms of nerve pain caused by diabetes. Depression Symptoms - Levine J, Barak Y, Gonzalves M, Szor H, Elizur A, Kofman O, Belmaker RH Double-blind, controlled trial of inositol treatment of depression Am J Psychiatry. (1995 May) Tabrizi R, Ostadmohammadi V, Lankarani KB, Peymani P, Akbari M, Kolahdooz F, Asemi Z The effects of inositol supplementation on lipid profiles among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials. Lipids Health Dis. (2018-May-24)

Another study in people with OCD found that 18 grams of inositol each day improved symptoms better than a placebo ( 5). Studies of inositol supplements have used higher amounts than typically found in food, with doses of up to 18 grams per day ( 1, 4). R.Z., et al., Risk factors of vitamin B(12) deficiency in patients receiving metformin. Arch Intern Med, 2006. 166(18): p. 1975-9. Susuki S et al. Urinary chiro-inositol excretion is an index marker of insulin sensitivity in Japanese type II diabetes. Diabetes Care. 1994 Dec;17(12):1465-8. Schizophrenia symptoms - Levine J, Goldberger I, Rapaport A, Schwartz M, Schield C, Elizur A, Belmaker RH, Shapiro J, Agam G CSF inositol in schizophrenia and high-dose inositol treatment of schizophrenia Eur Neuropsychopharmacol. (1994 Dec)

Gestational Diabetes Risk - D'Anna R, Di Benedetto V, Rizzo P, Raffone E, Interdonato ML, Corrado F, Di Benedetto A Myo-inositol may prevent gestational diabetes in PCOS women Gynecol Endocrinol. (2012 Jun) Unfer V, Facchinetti F, Orrù B, Giordani B, Nestler J Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials Endocr Connect. (2017 Nov) Myo-inositol is one supplement in particular which has received widespread attention for the potential role it has to play in supporting women with PCOS. And much research to date indicates that this novel supplement has the potential to provide support for many of these key areas. This blog post has been critically reviewed to ensure accurate interpretation and presentation of the scientific literature by Dr. Jessica A McCoy, Ph.D. Dr McCoy has a master’s degree in cellular and molecular biology, and a doctorate in reproductive biology and environmental health. She currently serves as a University professor at the College of Charleston, South Carolina.

In a 2020 study published in the American Journal of Physiology - Endocrinology and Metabolism, researchers evaluated the insulin-sensitising mechanisms of myo-inositol in human endometrial cells exposed to a PCOS environment. The researchers concluded that “myo-inositol is a potential insulin-sensitising agent that could be used as an effective treatment option in women with PCOS by improving their metabolic parameters as well as their reproductive status.” 37 Inositol is a natural sugar found in small amounts in some foods, mainly fruit like oranges and melons. It’s also sometimes called vitamin B8 because of its vitamin-like properties.