Especially in patients with impaired renal function, prolonged use of high doses can result in hypermagnesaemia or hypercalcaemia and alkalosis which may give rise to gastric symptoms and muscular weakness (see below). Changes in gastric acidity, such as that caused by the ingestion of antacids, can affect the rate and degree to which some concurrently administered medicines are absorbed. Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. If you are taking any of the following medicines speak to your doctor or pharmacist before taking Rennie Spearmint because it can affect how these medicines work.

Rennie Antacids, Spearmint Flavour, 72 Count (Pack of 1) Rennie Antacids, Spearmint Flavour, 72 Count (Pack of 1)

Long term use of high doses can cause high blood levels of calcium and magnesium, especially in people with kidney conditions. Symptoms of this may include nausea, vomiting, upset stomach, constipation, diarrhoea, tiredness, muscular weakness, headache, kidney problems and impaired sense of taste. Rennie Peppermint fast-acting tablets get to work within minutes to provide effective relief from heartburn, indigestion and acid reflux. You don't have permission to access "http://www.savers.co.uk/Health-%26-Wellbeing/Stomach-and-Bowel/Heatburn-%26-Indigestion-Tablets/Rennie-Spearmint-96s/p/36871" on this server. Rennie should not be used in patients with hypercalciuria (see also section 4.3). Prolonged use increases the risk of formation of renal calculi. The stated dose should not be exceeded. If, after 14 days of treatment, symptoms persist or only partly disappear the patient should consult a doctor.Drink plenty of water and consult your doctor or pharmacist. Symptoms of an overdose include nausea and vomiting, tiredness, constipation and muscular weakness. No increased risks of congenital defects have been observed after the use of this product during pregnancy. Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. Long term uses at high doses can result in undesirable effects such as hypercalcaemia, hypermagnesaemia and milk-alkali syndrome, especially in patients with renal insufficiency. Hypersensitivity reactions have very rarely been reported. Clinical symptoms may include rash, urticaria, pruritus, angioedema, difficulty in breathing and anaphylaxis.

PROFESSIONAL INFORMATION - Bayer PROFESSIONAL INFORMATION - Bayer

If you are taking any of the following medicines speak to your doctor or pharmacist before taking Rennie Peppermint because it can affect how these medicines work. Calcium and magnesium are excreted in human milk, but at therapeutic doses of the product no effects on the breastfed newborns/infants are anticipated.

Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity. The maximum recommended daily dose should not be exceeded and should not be taken for more than 2 weeks. If symptoms persist or only partly disappear after 2 weeks, medical advice should be sought. Caution should be exercised in patients with mild to moderate impairment of renal function (see section 4.3 – contraindication in severe renal insufficiency). If Rennie is used in such patients, plasma calcium, phosphate and magnesium levels should be regularly monitored. In vitro acid neutralisation studies (artificial stomach model) showed that Rennie increases stomach pH from pH 1.5-2 to pH 3 in 40 seconds and is able to reach pH 4 in 1 minute 13 seconds. The maximum level of pH achieved in the model was pH 5.24.

Rennie Antacids, Spearmint Flavour Heartburn Relief and

You don't have permission to access "http://www.savers.co.uk/Health-%26-Wellbeing/Stomach-and-Bowel/Heatburn-%26-Indigestion-Tablets/Rennie-Peppermint-96s/p/36905" on this server. Thiazide diuretics reduce the urinary excretion of calcium. Due to an increased risk of hypercalcaemia, serum calcium should be regularly monitored during concomitant use of thiazide diuretics. A small amount of calcium and magnesium may be absorbed, but in healthy subjects is usually rapidly excreted by the kidney. Always take this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you.

Calcium carbonate has a rapid and powerful neutralising action. This effect is increased by the addition of magnesium carbonate which also has a strong neutralising action. Calcium and magnesium carbonates react with excess acid in the gastric medium to produce soluble chlorides.