Janeway's Immunobiology

Product Information

We are continually exposed to microorganisms, many of which cause disease, and yet become ill only rarely. Susceptibility to autoimmune disease is controlled by environmental and genetic factors, especially MHC genes Protective immunity can be induced by injecting DNA encoding microbial antigens and human cytokines into muscle

Activated macrophages secrete a range of cytokines that have a variety of local and distant effectsTransmembrane and secreted forms of immunoglobulin are generated from alternative heavy-chain transcripts

The target of T cell-mediated autoimmunity is difficult to identify owing to the nature of T-cell ligands Co-stimulatory and inhibitory receptors modulate antigen receptor signaling in T and B lymphocytes. The humoral immune response is initiated when B cells that bind antigen are signaled by helper T cells or by certain microbial antigens alone Modulation of the immune system might be used to inhibit immunopathological responses to infectious agents Mucosa-associated lymphoid tissue is located in anatomically defined microcompartments throughout the gut

Contents

The 9th edition also includes updates on recent developments in multiple immunology subfields. Notably, the section on innate immunity has added a discussion of immune effector modules, which are critical to understanding the pathogenesis of inflammatory bowel disease, intestinal infection, and several other diseases. The section on therapeutics now contains a discussion of chimeric antigen receptors, an active and important area of cancer immunotherapy research. A particularly significant feature of this edition is an overhaul of the end-of-chapter questions and the addition of an instructors’ question bank. The 9th edition replaces the handful of often open-ended review questions at the end of each chapter with multiple-choice and true-false questions, providing an easier avenue for instructors to test the material. The two classes of MHCmolecule have distinct subunit structures but similar three-dimensional structures. / 3-15 Peptides are stably bound to MHC molecules, and also serve to stabilize the MHC molecule on the cell surface Allergy can be treated by inhibiting either IgE production or the effector pathways activated by cross-linking of cell-surface IgE Complement is a system of plasma proteins that interacts with pathogens to mark them for destruction by phagocytes The invariant chain directs newly synthesized MHC class II molecules to acidified intracellular vesicles