In studies in healthy subjects characterized as extensive metabolisers of dextromethorphan (antitussive drug and CYP2D6 probe substrate), terbinafine increased the dextromethorphan/dextrorphan metabolic ratio in urine by 16- to 97-fold on average. Thus, terbinafine may convert extensive CYP2D6 metabolisers (genotype) to poor metaboliser status (phenotype).

The cream, gel and spray usually start to work within a week, and the tablets can take between 2 weeks and a few months to work. Central nervous system or neurological problems: Headaches, dizziness, vertigo, light-headedness, decreased concentration levels, paraesthesia (pins and needles)Terbinafine". Pharmaceutical Benefits Scheme: A-Z list. Australian Government. Archived from the original on 2014-02-12.

Stevens-Johnson syndrome, toxic epidermal necrolysis), erythema multiforme, toxic skin eruption, dermatitis exfoliative, dermatitis bullous Use the solution after a shower or bath. Before using the solution, make sure your feet are dry, including between your toes. A standard battery of in vitro and in vivo genotoxicity tests revealed no evidence of mutagenic or clastogenic potential.Squeeze out a small amount of the cream or gel onto your finger (enough to put a thin layer on your skin). This accumulation results in therapeutic levels of terbinafine even after 80 days following one week treatment of 250mg/day. Different dosing schedules have been proposed such as 500mg/day for one week or 250mg/day for two weeks each followed by a drug-free period of three or two weeks, totaling 3 months of treatment including the drug-free periods. Such intermittent dosing schedules appear to be as effective as continuous regimens. [17] Chemistry [ edit ]