The defective enzyme doesn’t break down folate vitamins properly (of which folic acid is one), which can cause high homocysteine, which can increase your risk of coronary heart disease (arteriosclerotic vascular disease or venous thrombosis), and related heart and BP conditions, as well as increasing your risk for dementia. Methylated vitamins are a type of natural supplement that provide bioavailable nutrients to support methylation in the body. Methylation is a process where a methyl group (one carbon and three hydrogen atoms) is added to a molecule, changing its function. This process is important for a wide range of physiological processes, including energy production, DNA synthesis, and neurotransmitter synthesis. Those taking individual supplements: “Those who take a variety of nutritional supplements should evaluate whether taking a multivitamin along with their other pills will result in excessive intake of nutrients,” says Manaker. This might be a great supplement choice if you are vegan or vegetarian, and that's not just because it's certified vegan. Our bodies absorb only about 1% of the B12 we get from supplements, and the main food sources of B12 are animal foods. Because of this, nutrition experts recommend that vegans supplement with over 10,000% of the daily value of vitamin B12 each day and that vegetarians who eat dairy and eggs take this amount of B12 a few times per week. Nordic Naturals B-complex provides this exact amount of B12. When selecting personalized vitamins and natural supplements, it is important to choose high-quality products from reputable sources. Look for products that are third-party tested and free from harmful additives and fillers. Create a Routine

Vitamin B complex is a group of eight essential vitamins that play a crucial role in maintaining good health. These vitamins are water-soluble, which means that they are not stored in the body and need to be replenished regularly through diet and supplementation. Depression, anxiety, PMS, PMDD, post-partum depression, chronic fatigue and fibromyalgia. Pregnancy can exacerbate a B12 deficiency because high amounts of B12 are needed by the fetus, thus leaving the woman more depleted than she was pre-pregnancy and setting her up for post-partum depression. For most healthy individuals eating a well-balanced diet, B-complex supplements are not necessary. B vitamins are found in a wide variety of foods in different amounts, including leafy greens, salmon, legumes, eggs, milk, beef, and whole grains. Methyl groups have a hand in nearly every bodily function, from brain chemistry to the nervous system. de Jager, C.A., Oulhaj, A., Jacoby, R., Refsum, H. and Smith, A.D. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry, 27: 592-600. doi:10.1002/gps.2758

With Nordic Naturals B-Complex, you'll get a dose of all eight B vitamins, ranging from 83% to 10,417% of your daily needs. Nordic Naturals prioritizes the forms of the vitamins that are activated and more readily absorbed by your body. Separately, as of November 2022, the FDA prohibits nicotinamide mononucleotide (NMN) to be sold as a supplement while they investigate its potential usage as a drug. Because this mandate is new, you will likely still see this ingredient on the market until the regulation is fully enforced. The B-complex vitamins we recommend in this article do not contain nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN). Oulhaj A, Jernerén F, Refsum H, Smith AD, de Jager CA. Omega-3 fatty acid status enhances the prevention of cognitive decline by B vitamins in mild cognitive impairment. J Alzheimers Dis. 2016;50(2):547-557. doi:10.3233/JAD-150777 Because multivitamins contain nutrients that can be toxic in excess, it’s important to choose a supplement that is third-party tested and verified to ensure that the levels on the label match what is in the supplement.

Adding methylated vitamins to your daily routine can provide significant benefits for your overall health and wellness. Here are some tips for integrating them into your daily regimen: Determine Your NeedsThe first thing you need to do is avoid any supplements that have synthetic forms of the B vitamins in them. For instance, any supplement with folic acid is no good – this is just the synthetic, inactive form of folate.

Homocysteine is poorly converted to glutathione, which is your body’s chief antioxidant and detoxifier. You are then more susceptible to stress and toxin buildup. Research has shown that methylcobalamin plays a vital role in energy production, nerve function, and cognitive health. It also supports methylation, which is critical for efficient cellular function and DNA synthesis. Dahele A, Ghosh S. Vitamin B12 deficiency in untreated celiac disease. Am J Gastroenterol. 2001;96(3):745-750. doi:10.1111/j.1572-0241.2001.03616.x As you incorporate methylated vitamins into your routine, be open to adjusting your intake as needed. Monitor how your body responds and make changes accordingly. This may involve adjusting the dosage, timing, or frequency of your supplements. Fortunately, medical technology has progressed far enough to offer methylated vitamins. In fact, for most professional level supplement providers, methylated vitamins have been the standard for some time, and the retail space has caught up. This is good news, and not only for those with the MTHFR mutation. Everyone can benefit from the active state of methylated vitamins. The Power of Active VitaminsThe MTHFR enzyme works with the folate (vitamin B9), breaking it down from 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate Older adults: B-complex supplementation may have some benefit on cognitive function for older adults who have mild cognitive impairment or those without cognitive impairment. Older adults may be at particularly high risk of vitamin B12 deficiency, as they are often less able to absorb the micronutrient. Supplementation may help prevent or correct related issues, including issues with red blood cell formation and psychiatric symptoms. Why do you need to care about methylation? What is it anyway? Although it sounds complex, it’s actually a simple but essential chemical process that is happening constantly in your body. Methylation involves adding a 'methyl group' onto other chemical compounds which then allows the body to do most of its processes. Methionine is converted in your liver into SAM-e (s-adenosylmethionine), which is anti-inflammatory, supports your immune system, helps produce then breakdown of your brain chemicals serotonin, dopamine and melatonin, and is involved in the growth, repair and maintenance of your cells.