Paul Harris in Peshawar (November 25, 2001). "Victorious warlords set to open the opium floodgates". London: Observer.guardian.co.uk . Retrieved March 21, 2010. W. Travis Hanes III; Frank Sanello (February 1, 2004). The Opium Wars: The Addiction of One Empire and the Corruption of Another. Sourcebooks. pp.88–. ISBN 978-1-4022-5205-1. Chandra, Siddharth (2008). "Economic Histories of the Opium Trade". Archived from the original on September 28, 2013.

a b P. G. Kritikos & S. P. Papadaki (January 1, 1967). "The early history of the poppy and opium". Journal of the Archaeological Society of Athens. Hall, Wayne; Weier, Megan (2017). "Lee Robins' studies of heroin use among US Vietnam veterans". Addiction. 112 (1): 177. doi: 10.1111/add.13584. PMID 27650054. S2CID 206974500 . Retrieved July 26, 2022. Opiates like opium, morphine and codeine are depressant (sedative) drugs. They slow down body functions like heart rate and breathing. They also reduce pain and have been used to synthesise a very wide range of painkilling drugs. Unfortunately, opiate drugs have the potential to be addictive.

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a b c d e Brown Richard Harvey (2002). "The Opium Trade And Opium Policies In India, China, Britain, And The United States: Historical Comparisons And Theoretical Interpretations". Asian Journal of Social Science. 30 (3): 623. doi: 10.1163/156853102320945420.

Manuscripts of Pseudo-Apuleius's 5th-century work from the 10th and 11th centuries refer to the use of wild poppy Papaver agreste or Papaver rhoeas (identified as P. silvaticum) instead of P. somniferum for inducing sleep and relieving pain. [27]Ladenburg, Thomas (1974). "Chapter 1, The French in Indochina" (PDF). University of Houston. Archived (PDF) from the original on March 1, 2023 . Retrieved March 21, 2023.

Drug Addiction Research and the Health of Women – pg. 33–52" (PDF). Archived from the original (PDF) on August 22, 2008 . Retrieved March 21, 2010. Hai guan zong shui wu si shu (1889). The poppy in China. Shanghai; Statistical Dept. of the Inspectorate General of Customs. Thelwall, A. S. (1839). The iniquities of the opium trade with China; being a development of the main causes which exclude the merchants of Great Britain from the advantages of an unrestricted commercial intercourse with that vast empire. With extracts from authentic documents. London: Wm. H. Allen and Co.

E. Guerra Doce (January 1, 2006). "Evidencias del consumo de drogas en Europa durante la Prehistoria". Trastornos Adictivos (in Spanish). 8 (1): 53–61. doi: 10.1016/S1575-0973(06)75106-6. Archived from the original on May 15, 2008 . Retrieved May 10, 2007. (includes image) Use of opium as a cure-all was reflected in the formulation of mithridatium described in the 1728 Chambers Cyclopedia, which included true opium in the mixture. After oral administration, opium bioavailability is poor. 9 In the form of opioid tincture, the Cmax and AUC of opium are between 16-24 mg/ml and 3237-6727 ng/ml.h, respectively. 4 Volume of distribution Smoking of opium came on the heels of tobacco smoking and may have been encouraged by a brief ban on the smoking of tobacco by the Ming emperor. The prohibition ended in 1644 with the coming of the Qing dynasty, which encouraged smokers to mix in increasing amounts of opium. [1] In 1705, Wang Shizhen wrote, "nowadays, from nobility and gentlemen down to slaves and women, all are addicted to tobacco." Tobacco in that time was frequently mixed with other herbs (this continues with clove cigarettes to the modern day), and opium was one component in the mixture. Tobacco mixed with opium was called madak (or madat) and became popular throughout China and its seafaring trade partners (such as Taiwan, Java, and the Philippines) in the 17th century. [47] In 1712, Engelbert Kaempfer described addiction to madak: "No commodity throughout the Indies is retailed with greater profit by the Batavians than opium, which [its] users cannot do without, nor can they come by it except it be brought by the ships of the Batavians from Bengal and Coromandel." [20] Production of thebaine and oripavine". April 20, 2004. Archived from the original on September 5, 2012 . Retrieved May 10, 2007.

W. R. Martin & H. F. Fraser (September 1, 1961). "A comparative study of subjective and physiological effects of heroin and morphine administered intravenously in postaddicts". Journal of Pharmacology and Experimental Therapeutics. 133 (3): 388–399. PMID 13767429 . Retrieved June 6, 2007. William Travis Hanes; Frank Sanello (2004). Opium Wars: The Addiction of One Empire and the Corruption of Another. Sourcebooks, Inc. pp.78–. ISBN 978-1-4022-0149-3.

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During the Communist era in Eastern Europe, poppy stalks sold in bundles by farmers were processed by users with household chemicals to make kompot (" Polish heroin"), and poppy seeds were used to produce koknar, an opiate. [99] Obsolescence [ edit ] Apothecary vessel for storage of opium as a pharmaceutical, Germany, 18th or 19th century Chen P, Braithwaite RA, George C, Hylands PJ, Parkin MC, Smith NW, Kicman AT: The poppy seed defense: a novel solution. Drug Test Anal. 2014 Mar;6(3):194-201. doi: 10.1002/dta.1590. Epub 2013 Dec 12. [ Article] Darke S, Zador D (December 1996). "Fatal heroin 'overdose': a review". Addiction. 91 (12): 1765–72. doi: 10.1046/j.1360-0443.1996.911217652.x. PMID 8997759. Opium Factories of Bihar – Bihargatha". Bihargatha.in. Archived from the original on September 10, 2011 . Retrieved October 7, 2011. Ahmad, Diana L. The Opium Debate and Chinese Exclusion Laws in the Nineteenth-century American West (University of Nevada Press, 2007). Drugs and Racism in the Old West.