If you use too much terbinafine cream, gel or spray or use it more often than you need to, it may make your skin irritated or red. In a two-year oral carcinogenicity study in mice, no neoplastic or other abnormal findings attributable to treatment were made up to doses of 130 (males) and 156 (females) mg/kg a day. In the majority of liver failure cases the patients had serious underlying systemic conditions and a causal association with the intake of Lamisil was uncertain.

During high-dose studies in monkeys, refractile irregularities were observed in the retina at the higher doses (non-toxic effect level 50mg/kg).Lamisil AT 1% Cream contains cetyl alcohol and stearyl alcohol which may cause local skin reactions (e. Patients with these symptoms should discontinue taking oral terbinafine and the patient's liver function should be immediately evaluated.

Similar increase in exposure may occur when other drugs which inhibit both CYP2C9 and CYP3A4 such as ketoconazole and amiodarone are concomitantly administered with terbinafine. Where co-administration of such agents is necessary, the dosage of Lamisil may need to be adjusted accordingly. The experience with topical LAMISIL in children is still limited and its use cannot therefore be recommended.It's important to keep taking or using terbinafine until you finish the course, even if your symptoms get better. In studies in healthy subjects characterized as extensive metabolisers of dextromethorphan (antitussive drug and CYP2D6 probe substrate), terbinafine increased the dextromethorphan/dextrorphan metabolic ratio in urine by 16- to 97-fold on average. It is freely soluble in methanol and methylene chloride, soluble in ethanol, and slightly soluble in water. It is also available as a generic medication in the United States, the United Kingdom, Belgium, Switzerland, Brazil, Mexico, Canada and France. In India, terbinafine hydrochloride is available in topical form under the brand names Triabin by Medley Pharmaceuticals, Sebifin (Sun Pharma), Zimig (GSK Pharma) and mycoCeaze (Progreś Laboratories).

If you forget to use your terbinafine cream, gel or spray, just use it as soon as you remember and then keep following your usual routine. If you're taking the tablets, the most common side effects are having a smaller appetite than usual, pain in your joints or muscles, or upset stomach.g. tolbutamine, terfenadine, triazolam, oral contraceptives) with exception of those metabolised through CYP2D6 (see below). Other names include Terbinaforce ( Mankind Pharma) and Tafine (Deurali Janta Pharmaceuticals Pvt Ltd.