Get immediate medical advice in the event of an overdose with this medicine, even if you feel well, because of the risk of delayed, serious liver damage. The proposed mechanism is induction of hepatic microsomal enzymes during chronic alcohol use, which may result in accelerated metabolism of acetaminophen and increased production of potentially hepatotoxic metabolites.

Phenylephrine relieves a blocked nose by causing the blood vessels in the linings of the nasal passages and sinuses to contract and narrow. If you're taking medicines for high blood pressure you shouldn't take Lemsip cough max for mucus cough and cold, because the decongestant may make your blood pressure medicine less effective. Rita Ghelani (BPharm, MRPharmS) Pharmacist A UK registered practising pharmacist with over 20 years' experience, Rita is a member of the medical journalists’ association (MJA) and has a wealth of experience in community pharmacy.Dr Roger Henderson Dr Roger Henderson is a Senior GP, national medical columnist and UK medical director for LIVA HealthcareHe appears regularly on television and radio and has written multiple books. Relieving the symptoms of colds and flu, such as headache, sore throat, aches and pains, fever, blocked nose and sinuses, and sinus pain. Confusion about dosing of this drug may be caused by the availability of different formulas, strengths, and dosage instructions for children of different ages.

Many of these will also contain paracetamol, phenylephrine hydrochloride and guaifenesin among their ingredients. Seek advice before using if you are breast feeding, pregnant, planning to become pregnant, or suffer from allergies. Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine. You should also avoid taking more than one paracetamol-containing medicine at the same time, as this can easily result in exceeding the maximum dose of paracetamol. Do not take this medicine with any other products that contain paracetamol, as this can easily result in exceeding the maximum dose of paracetamol.After an overdose, the half-life can range from 4 to 8 hours depending on the severity of injury to the liver, as it heavily metabolizes acetaminophen. Adults and adolescents aged 12 years and over should take one sachet up to four times a day as needed. Excessive caffeine consumption can cause insomnia, restlessness, anxiety, irritability, headaches and palpitations. Expectorants such as guaifenesin are used to treat a productive, chesty or mucus cough, where you cough up phlegm. Peak blood levels of free acetaminophen are not reached until 3 hours after rectal administration of the suppository form of acetaminophen and the peak blood concentration is approximately 50% of the observed concentration after the ingestion of an equivalent oral dose (10-20 mcg/mL).