When Cybertron entered the Sol system, its gravitational pull affected Optimus and caused him to crash land on his homeworld, its atmosphere reviving him. He is a born leader, a natural tactician, a dedicated never-say-die fighter and a master of improvisation in the face of adversity. There’s also a dedicated mobile app for the robot where you can select different moves and poses for him to carry out or even program your own. T. and the Autobots traveled to Chernobyl, where they found a mysterious piece of a metal part before coming under attack by Shockwave's Driller. Jazz raised objections to leave Bumblebee behind, but Prime remained firm in his belief of not harming the humans.

Realizing that the entire Autobot Team and the humans would need a means to travel to Peru, Optimus enlisted the help of Stratosphere to fly the team, remaining mostly silent in the flight to Peru, while hoping that Bumblebee could be revived with an Energon transfusion. Arriving last at the location, he noticed that Mirage had brought a human, revealed by Arcee to be Noah Diaz, to their location.Optimus's decision proved a foolish one however, as he exhausted his Energon in the vicinity of Jupiter and fell into stasis lock, drifting through space. Millennia in the ice had done nothing to lessen Megatron's hatred of his brother, and he launched himself in jet mode at the Autobot leader.

Mearing explained that it was kept secret from everyone except a very few people and brought in Buzz Aldrin to explain. The model comes equipped with 80 different sound effects voiced by the original voice actor himself and can be controlled entirely through 25 of your own voice commands such as “rollout,”“convert” and “attack.

He was able to defeat multiple incarnations of Unicron, an army of undead cybertronians, multiple insecticons and armies of vehicons on his own. Optimus and the other Autobots headed further into the city to open a way for Sam, Epps and their team to make their way to a building where they would attempt to shoot down the Control Pillar. Optimus then allied with the Knights and they flew off in the Knight Ship to confront Megatron and Quintessa on Cybertron. After the arrival of Sam Witwicky, Optimus successfully revived Sentinel who initially attacked him, before calming down after learning where they were. Megatron asked for a truce, saying all he wanted was to be in charge again and asked Optimus what he would be without him.

Wounded emotionally by the loss of Bumblebee, Optimus tried to pin the blame of the situation onto Noah, with the human placing the blame back on Optimus.

Seeing no other option to revitalize Cybertron, having merged the Allspark's energies with the Matrix, Optimus sacrificed his life, plunging the Matrix into the planet's core so that it could breed new life. He noticed a fragment of the AllSpark in Megatron's chest cavity and removed it, then permitted the humans to dispose of the Decepticon corpses. Almost everything else is identical, right down to the over 5,000 components that go into the robot including 60 microchips, 27 servos, and accessories like Prime’s blaster and energy axe that can be swapped in as needed. Optimus tried to save himself from the transwarp vortex sucking him into the closing portal, only to be helped by Noah grabbing his axe.