This is a particularly intense version of a gag for the lover of working gags. How to classify it exactly is hard to say. Is it a ball gag or a tongue gag or a bit guard? One doesn’t know.

NCBI Bookshelf Biochemistry, Glycosaminoglycans - StatPearls - NCBI Bookshelf

Keratan sulfate has been well-studied for its functional role in both the cornea and the nervous system. The cornea comprises the richest known source of keratan sulfate in the body, followed by brain tissue. [14] The role of keratan sulfate in the cornea includes regulation of collagen fibril spacing that is essential for optical clarity, as well as optimization of corneal hydration during development based on its interaction with water molecules. As with other GAGs, the degree of sulfation of keratan sulfate determines its functional status. Abnormal sulfation patterns of keratan sulfate due to specific genetic mutations result in increased opacity of the cornea and result in visual disturbances. [14] Older dogs tend to gag more because, just like people, when they get older, they tend to produce more mucus and their throats are more sensitive. It is very thin in the frenulum area and there is a designated area that can be cut out if you need more room for the frenulum. For advanced users, there is a sea of options. From beginner to expert ones, you will have options for any play you want. Some examples of advanced ball gags are: I screamed and yelled, “harder, harder”. The words were only in my head as it was only an indistinctive mumble for him but he understood every word. Thrusting ever harder, he made me orgasm in a way that made my whole body shake.Signs of a foreign object caught in the esophagus include gagging, retching, drooling, and regurgitating. Pathophysiological processes related to GAGs are very broad in range due to the ubiquitous nature of GAGs in the body. This section will describe how GAGs are involved in the pathophysiology of various infectious processes as well as a group of rare genetic diseases known as Mucopolysaccharidoses (MPS) related to the metabolism of GAGs.

Bone Gag [𝗙𝗿𝗲𝗲] - Gumroad

The noteworthy exception to the following steps in GAG biosynthesis is hyaluronic acid (HA). Instead of undergoing modification and sulfation in the Golgi apparatus, the HA precursor sugars UDP-glucuronic acid and UDP- N-acetylglucosamine are transported from the cytoplasm to the plasma membrane for further processing without sulfation, which leads to the production of HA. [4] In older dogs, infected teeth and tumors are the most common causes of rhinitis and sinusitis. RoundwormsHere at DDLG Playground we are passionate about cute, kinky, and kawaii fashion surrounding the DDLG / CGL / ABDL / BDSM and littlespace communities! We ship WORLDWIDE for free AND discreetly so you can easily find and indulge in cute clothing & accessories that appeal to you or your special someone's personal ageplay style! The cellular organelles involved in the synthesis and modification of GAGs to their final, bioactive structure are numerous and differ based on the unique GAG synthesized. This section will provide an overview of the cellular mechanisms involved in GAG biosynthesis. It is important to note that unlike proteins and nucleic acids, GAG biosynthesis is a non-template driven process that occurs through the combined action of several tissue-specific enzymes. [2]