THE Fur Trade Benevolent Society is a registered charity (No 38 BEN) and was established in 1929 for the benevolent or charitable purpose of providing financial or other assistance to persons who had been working in the fur trade and who now find themselves in need. I played my football in the early 60s for St George of England School and Bootle Boys and when my mother died all my football pictures went missing. My main interest is in the process of cell division, particularly mitosis the process by which cells segregate their duplicated chromosomes to form two separate daughter cells. This area of research is of increasing interest in the development of therapies for anti-proliferative diseases such as cancer. For example the anti-cancer drug taxol inhibits the formation of the mitotic spindle microtubule network which is required to correctly separate the duplicated chromosomes (see figure above). Cells treated with taxol arrest in mitosis and eventually die, so rapidly proliferating cancer cells are sensitive to taxol treatment compared to most body tissues. However taxol also affects the structural microtubules which are crucial to nerve cell function, resulting in side-effects which must be carefully managed in patients. Anti-mitotic drugs which target proteins exclusively involved in cell division and not required for other processes would therefore be of major benefit.

In recent years the number of people involved in the active trade in the UK has diminished and the society is unable to rely on information from members of the trade to alert us to deserving cases particulary outside London.Higgins, Julie; Midgley, Carol A.; Bergh, Anna-Maria; Bell, Sandra M.; Askham, Jonathan M.; Roberts, Emma; Binns, Ruth K.; Sharif, Saghira M.; Bennett, Christopher; Glover, David M.; Woods, C. Geoffrey; MorrisonBond, Ewan E. and Bond, Jacquelyn I remember playing at Anfield against Liverpool Boys - the score was 0-0. If possible can you get me the name of anyone who took the Schoolboys' pictures in the 60s. To the best of my knowledge and belief, the Tories - under Margaret Thatcher - did commit themselves to a radical overhaul of the domestic rating system, which indeed precipitated the community charge. Anilino-4-(thiazol-5-yl)pyrimidine CDK Inhibitors: Synthesis, SAR Analysis, X-ray Crystallography, and Biological Activity (2004-03-25) Discovery of (E)-3-((styrylsulfonyl)methyl)pyridine and (E)-2-((styrylsulfonyl)methyl)pyridine derivatives as anticancer agents: synthesis, structure-activity relationships, and biological activities. (2014-03-27)

Synthesis and biological activity of 2-anilino-4-(1H-pyrrol-3-yl) pyrimidine CDK inhibitors (2004-08-16) If you would like to get in touch with the new 6th Liverpool, the anchor section and company section meet in the church centre on Wednesday nights from 6.15 pm onwards. This inappropriate attentionseeking ought not to be applauded nor encouraged, not only as it causes the subject great neurosis and anxiety in trying to live up to the projected images as peddled by market forces, but it also sets them into financial dire straits. Chahrour O, Abdalla A, Lam F, Midgley C, Wang S. Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors. Bioorg Med Chem Lett. 2011 May 15;21(10):3066-9. Lu T, Goh AW, Yu M, Adams J, Lam F, Teo T, Li P, Noll B, Zhong L, Diab S, Chahrour O, Hu A, Abbas AY, Liu X, Huang S, Sumby CJ, Milne R, Midgley C, Wang S. Discovery of (E)-3-((styrylsulfonyl)methyl)pyridine and (E)-2-((styrylsulfonyl)methyl)pyridine derivatives as anticancer agents: synthesis, structure-activity relationships, and biological activities. (2014) J Med Chem. 2014 Mar 27;57(6):2275-91.

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Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors (2011-03-17) Myself and several colleagues were rather surprised at the comments of Arts Editor Joe Riley. To give six out of 10 for a truly magnificent concert was very unfair. THE concert at the Philharmonic Hall on Thursday 6 February was wonderful. The orchestra were on top form.

We were heartbroken and didn't know how to tell them so we are trying to find some who who has a similar tape. Help! We are willing to pay Our junior section meets in St Oswald's school on Tuesday from 6.30 pm till 8.00 pm. Both buildings are in Ronald Ross Avenue, Netherton. Hope to hear from you Mr H Pemberton or any other old boys. I am John Hanson a serving officer with the 6th Liverpool Company here at St Oswald's Church of England church in Netherton.

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My daughter and her husband recently arranged to see Manchester football ground. They also went to Liverpool football ground on the booked tours. They have twin 11-year-old boys who are big football fans, one Liverpool the other United. I HAD to tell you of the wonderful treatment I had at the Alfred Jones Memorial Hospital Garston. God bless them all.

For instance, a growing minority of 'adult girls' in Liverpool appear as if they are about to deliver 'live on stage' a la Britney Spears although they may be travelling on the grimiest of buses en-route to the local supermarket. IN reply to Carol Midgley's article Liverpool Capital Of Cool (ECHO February 15) she is either greatly deluded or bent on assisting the corporate world in exploiting the populous of Liverpool into murdering themselves with credit card debt.

Biological significance of a small highly conserved region in the N terminus of the p53 tumour suppressor protein (2001-11-02) Of course, Mr Riley must give his opinion, but we feel on this occasion he was very wrong. The applause at the end of the concert would bear this out. Discovery and characterization of 2-Anilino-4-(Thiazol-5-yl)Pyrimidine transcriptional CDK inhibitors as anticancer agents (2010-10-29) Lu, Tiangong; Goh, Aik Wye; Yu, Mingfeng; Adams, Julian; Lam, Frankie; Teo, Theodosia; Li, Peng; Noll, Ben; Zhong, Longjin; Diab, Sarah; Chahrour, Osama; Hu, Anran; Abbas, Abdullahi Y,; Liu, Xiangrui; Huang, Shiliang; Sumby, Christopher J.; Milne, Robert; Midgley, Carol and Wang, Shudong