Cocoa also contains compounds like flavonols and methylxanthines, and some studies have investigated its potential as a functional food ( 11). Parkinson disease: Taking caffeine with creatine might make Parkinson disease worsen faster. If you have Parkinson disease and take creatine, use caffeine with caution. Goldstein, E. R., Ziegenfuss, T., Kalman, D., Kreider, R., Campbell, B., Wilborn, C., Taylor, L., Willoughby, D., Stout, J., Graves, B. S., Wildman, R., Ivy, J. L., Spano, M., Smith, A. E., and Antonio, J. International society of sports nutrition position stand: caffeine and performance. J Int Soc Sports Nutr 2010;7(1):5. View abstract.

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Chroscinska-Krawczyk, M., Ratnaraj, N., Patsalos, P. N., and Czuczwar, S. J. Effect of caffeine on the anticonvulsant effects of oxcarbazepine, lamotrigine and tiagabine in a mouse model of generalized tonic-clonic seizures. Pharmacol Rep. 2009;61(5):819-826. View abstract. Taking caffeine along with riluzole might decrease how fast the body breaks down riluzole. This might increase the effects and side effects of riluzole.

Chik, Y., Hoesch, R. E., Lazaridis, C., Weisman, C. J., and Llinas, R. H. A case of postpartum cerebral angiopathy with subarachnoid hemorrhage. Nat.Rev.Neurol. 2009;5(9):512-516. View abstract.

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Birkett, N. J. and Logan, A. G. Caffeine-containing beverages and the prevalence of hypertension. J Hypertens.Suppl 1988;6(4):S620-S622. View abstract. Ahmed, I. Malignant hypertension and acute aortic dissection associated with caffeine-based ephedra-free dietary supplements: a case report. Cases.J 2009;2:6612. View abstract. Attwood, A., Terry, P., and Higgs, S. Conditioned effects of caffeine on performance in humans. Physiol Behav 3-3-2010;99(3):286-293. View abstract. Feldman, M. and Barnett, C. Relationships between the acidity and osmolality of popular beverages and reported postprandial heartburn. Gastroenterology 1995;108(1):125-131. View abstract. Addicott, M. A., Yang, L. L., Peiffer, A. M., Burnett, L. R., Burdette, J. H., Chen, M. Y., Hayasaka, S., Kraft, R. A., Maldjian, J. A., and Laurienti, P. J. The effect of daily caffeine use on cerebral blood flow: How much caffeine can we tolerate? Hum Brain Mapp. 2009;30(10):3102-3114. View abstract.This causes a relative increase in other signaling molecules, such as dopamine and norepinephrine ( 5, 6). An 8-ounce (240-mL) serving of green tea provides about 30–50 mg of caffeine, which is about half of the caffeine content of a cup of coffee ( 17). Gliottoni, R. C., Meyers, J. R., Arngrimsson, S. A., Broglio, S. P., and Motl, R. W. Effect of caffeine on quadriceps muscle pain during acute cycling exercise in low versus high caffeine consumers. Int J Sport Nutr Exerc.Metab 2009;19(2):150-161. View abstract. Normally, adenosine levels build up over the day, making you increasingly more tired and causing you to want to go to sleep.

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High blood pressure: Consuming caffeine might increase blood pressure in people with high blood pressure. But this does not seem to be a major concern in people who use caffeine regularly. Interestingly, consuming decaffeinated coffee was also linked to a 21% lower risk of diabetes. This indicates that other beneficial compounds in coffee can also protect against type 2 diabetes ( 36). SummaryEinother, S. J., Martens, V. E., Rycroft, J. A., and De Bruin, E. A. L-theanine and caffeine improve task switching but not intersensory attention or subjective alertness. Appetite 2010;54(2):406-409. View abstract. Astrup, A., Toubro, S., Cannon, S., Hein, P., Breum, L., and Madsen, J. Caffeine: a double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. Am.J.Clin.Nutr. 1990;51(5):759-767. View abstract. Therefore, it’s recommended to limit the amount of caffeine you consume at one time to 200 mg per dose ( 60, 61).