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Veglia, F., Sanseviero, E. & Gabrilovich, D. I. Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity. Nat. Rev. Immunol. 21, 485–498 (2021).

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This article is part of the Topical Collection: Special Issue on Big Data and Smart Computing in Network Systems Based on accumulated evidence in a century, GBC typifies chronic inflammation-associated cancers (CIACs) 4. The majority of GBCs reside in a harsh environment besieged by infectious (e.g., pathogens), chemical (e.g., pancreatic juice reflux), mechanical (e.g., gallstone irritation), metabolic (e.g., bile cholesterol supersaturation), and hydrodynamic (e.g., biliary sludge) stresses which, along with heightened cell division stress with aging, contribute to a multitude of microbial, cytotoxic, metabolic, genotoxic, and senescence-related inflammation processes 5, many of which have initiated and evolved from inflamed gallbladders for ~15 years or more 6. Fabbri, L., Chakraborty, A., Robert, C. & Vagner, S. The plasticity of mRNA translation during cancer progression and therapy resistance. Nat. Rev. Cancer 21, 558–577 (2021). Capkun S, Cagalj M, Srivastava MB (2006) Secure localization with hidden and mobile base stations. In: INFOCOMBiswas J, Wang E, Gaowei M, Liu W, Rahman O, Sadowski JT (2021) High quantum efficiency GaAs photocathodes activated with Cs, O2, and Te. AIP Advances 11:025321. doi: 10.1063/5.0026839 Alitalo, K., Tammela, T. & Petrova, T. V. Lymphangiogenesis in development and human disease. Nature 438, 946–953 (2005). Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Li H, Liu D, Dai Y, Luan TH, Shen XS (2015) Enabling efficient multi-keyword ranked search over encrypted mobile cloud data through blind storage. IEEE Trans Emerg Top Comput 3(1):127–138

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Yamagiwa, H. & Tomiyama, H. Intestinal metaplasia-dysplasia-carcinoma sequence of the gallbladder. Acta Pathol. Jpn. 36, 989–997 (1986). Bontpart T, Cheynier V, Ageorges A, Terrier N. 2015. BAHD or SCPL acyltransferase? What a dilemma for acylation in the world of plant phenolic compounds. New Phytologist 208: 695-707.Aibar, S. et al. SCENIC: single-cell regulatory network inference and clustering. Nat. Methods 14, 1083–1086 (2017). Wang, X. et al. Non-invasive detection of biliary tract cancer by low-coverage whole genome sequencing from plasma cell-free DNA: A prospective cohort study. Transl. Oncol. 14, 100908 (2021). Baker, S. et al. Cancer Hallmarks Analytics Tool (CHAT): a text mining approach to organize and evaluate scientific literature on cancer. Bioinformatics 33, 3973–3981 (2017). Xie H, Ben-Zvi I, Rao T, Xin T, Wang E (2016) Experimental measurements and theoretical model of the cryogenic performance of bialkali photocathode and characterization with MonteCarlo simulation. Physical Review Accelerators and Beams. doi: 10.1103/physrevaccelbeams.19.103401 Schworer, S., Vardhana, S. A. & Thompson, C. B. Cancer metabolism drives a stromal regenerative response. Cell Metab. 29, 576–591 (2019).

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International Cooperation Laboratory on Signal Transduction, National Center for Liver Cancer, Ministry of Education Key Laboratory on Signaling Regulation and Targeting Therapy of Liver Cancer, Shanghai Key Laboratory of Hepato-biliary Tumor Biology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China Newman, A. M. et al. Determining cell type abundance and expression from bulk tissues with digital cytometry. Nat. Biotechnol. 37, 773–782 (2019). humidity-sensitive genic male sterility; hybrid breeding; pollen wall; rice; very-long-chain fatty acids. Li H, Liu D, Dai Y, Luan T, Yu S (2018) Personalized search over encrypted data with efficient and secure updates in mobile clouds. IEEE Trans Emerg Top Comput 6(1):97–109 Based on the idea that the hardness of covalent crystal is intrinsic and equivalent to the sum of the resistance to the indenter of each bond per unit area, a semiempirical method for the evaluation of hardness of multicomponent crystals is presented. Applied to beta-BC2N crystal, the predicted value of hardness is in good agreement with the experimental value. It is found that bond density or electronic density, bond length, and degree of covalent bonding are three determinative factors for the hardness of a polar covalent crystal. Our method offers the advantage of applicability to a broad class of materials and initializes a link between macroscopic property and electronic structure from first principles calculation.Barkal, A. A. et al. CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy. Nature 572, 392–396 (2019).