Scotte F., Tourani J. M., Banu E., Peyromaure M., Levy E., Marsan S.,...Oudard S. (2005). Multicenter study of a frozen glove to prevent docetaxel-induced onycholysis and cutaneous toxicity of the hand. Journal of Clinical Oncology, 23( 19), 4424–4429. 10.1200/JCO.2005.15.651 [ PubMed] [ CrossRef] [ Google Scholar] Symptoms assessed at baseline and before every cycle of paclitaxel administration during outpatient care No significant difference in Neuropathic Pain Symptom Inventory scores for symptoms in hands ( p> .15) or feet ( p> .30); no significant difference in quantitative sensory testing results ( p> .15); and pain severity using the Brief Pain Inventory was increased for all measures across time de Lemos M. L., & Walisser S. (2005). Management of extravasation of oxaliplatin. Journal of Oncology Pharmacy Practice, 11( 4), 159–162. 10.1191/1078155205jp165oa [ PubMed] [ CrossRef] [ Google Scholar] Reduced incidence of ≥ grade 2 peripheral neuropathy in the intervention group (5.0%–9.1%) vs. the control group (22.5%–35.8%); p< .05 at the fourth cycle and p< .01 after the fifth cycle

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Chemotherapy-induced peripheral neuropathy may be associated with decreased quality of life, reduced functional abilities, and may prevent patients from returning to work ( Miltenburg & Boogerd, 2014; Mols, Beijers, Vreugdenhil, & van de Poll-Franse, 2014; Tofthagen, 2010; Zanville et al., 2016). Functional limitations of CIPN relate to hand pain, hand numbness affecting fine motor skills, and foot pain and numbness, which may cause difficulty walking ( Bhatnagar et al., 2014; Zanville et al., 2016). Symptoms and severity of CIPN are also associated with an increased risk of falls ( Tofthagen, Overcash, & Kip, 2012). Symptoms of CIPN contribute to feelings of depression and loss of purpose when patients lose the ability to engage in activities they enjoy ( Tofthagen, 2010). The duration of CIPN symptoms ranges from months to years following treatment and may be permanent ( Miltenburg & Boogerd, 2014). No statistically significant preservation of hand or foot cold sense, vibration perception, electrophysiological measurements Determine whether limb hypothermia is protective against paclitaxel-induced peripheral neuropathy and assess safety and tolerability Frozen Birthday Shirt , Elsa Birthday Shirts, Frozen Custom Shirt , Frozen Personalized Tee, Frozen Family Party shirts Shah A., Hoffman E. M., Mauermann M. L., Loprinzi C. L., Windebank A. J., Klein C. J., & Staff N. P. (2018). Incidence and disease burden of chemotherapy-induced peripheral neuropathy in a population-based cohort. Journal of Neurology, Neurosurgery, and Psychiatry, 89( 6), 636–641. 10.1136/jnnp-2017-317215 [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar]Correlation between motor nerve amplitude preservation at 6 months and degree of skin cooling achieved, which demonstrated statistical significance ( p< .0005)

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CTCAE results: Decrease in the incidence of ≥ grade 2 peripheral neuropathy in the intervention side ( p< .0001). The occurrence of ≥ grade 2 sensory neurotoxicity decreased from 76.1% to 21.4%, and that of motor neurotoxicity decreased from 57.1% to 26.2%Sato J., Mori M., Nihei S., Kumagai M., Takeuchi S., Kashiwaba M., & Kudo K. (2016). The effectiveness of regional cooling for paclitaxel-induced peripheral neuropathy. Journal of Pharmaceutical Health Care and Sciences, 2, Article number: 33 Sundar R., Bandla A., Tan S. S., Liao L. D., Kumarakulasinghe N. B., Jeyasekharan A. D.,...Wilder-Smith E. P. (2016). Limb hypothermia for preventing paclitaxel-induced peripheral neuropathy in breast cancer patients: A pilot study. Frontiers in Oncology, 6, 274 One of the two studies that applied a relatively lesser amount of cooling as defined in this review achieved statistically significant benefits in the severity of peripheral neuropathy ( Tsuyuki et al., 2016). This prospective, self-controlled study included 42 breast cancer patients who received compression therapy with two surgical gloves sized one size too small worn on the dominant hand, which resulted in a decrease in fingertip temperature on the intervention side. Subjects received nab-paclitaxel every 3 weeks for four cycles. Outcomes were measured using the CTCAE and the PNQ and were recorded at baseline, before each treatment cycle, and 1 week after nab-paclitaxel was administered. CTCAE results demonstrated a decrease in the incidence of ≥ grade 2 peripheral neuropathy on the intervention side ( p< .0001). The occurrence of ≥ grade 2 sensory neurotoxicity decreased from 76.1% to 21.4%, and that of motor neurotoxicity decreased from 57.1% to 26.2%. Patient Neuropathy Questionnaire results demonstrated significantly lower grades of peripheral neuropathy on the intervention side ( p< .0001).

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|Keep collections to yourself or inspire other shoppers! Keep in mind that anyone can view public collections - they may also appear in recommendations and other places. Minimalist IVF Milestone Cards, Fertility Milestone Cards, IVF Journey Cards, Keepsake Cards, IVF Announcement Sign, Ivf printableHershman D. L., Lacchetti C., & Loprinzi C. L. (2014). Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology Clinical Practice Guideline Summary. Journal of Oncology Practice, 10( 6), e421–e424. 10.1200/JOP.2014.001776 [ PubMed] [ CrossRef] [ Google Scholar] Similar benefit after subsequent chemo cycles (odds ratio: 0.59; 95% CI = 0.46–0.76, p< .0001), although analysis of impact of preexisting peripheral neuropathy not performed in statistics for late peripheral neuropathy group Pereira S., Fontes F., Sonin T., Dias T., Fragoso M., Castro-Lopes J. M., & Lunet N. (2016). Chemotherapy-induced peripheral neuropathy after neoadjuvant or adjuvant treatment of breast cancer: A prospective cohort study. Supportive Care in Cancer, 24( 4), 1571–1581. 10.1007/s00520-015-2935-y [ PubMed] [ CrossRef] [ Google Scholar] Small sample size with high dropout rate (29 down to 7) in part due to discomfort with intervention Frozen Elsa Ice Queen Girls Birthday Shirt, Frozen Birthday Shirt, Elsa Birthday shirt, Frozen Inspired Shirt, Frozen Applique Shirt

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Tofthagen C. (2010). Patient perceptions associated with chemotherapy-induced peripheral neuropathy. Clinical Journal of Oncology Nursing, 14( 3), E22–E28. 10.1188/10.CJON.E22-E28 [ PubMed] [ CrossRef] [ Google Scholar]

Tofthagen C., Overcash J., & Kip K. (2012). Falls in persons with chemotherapy-induced peripheral neuropathy. Supportive Care in Cancer, 20( 3), 583–589. 10.1007/s00520-011-1127-7 [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar] Compound motor action potential amplitudes of motor nerves more preserved at 3 months post treatment. Did not achieve statistical significance. Extensor digitorum brevis compound motor action potential amplitudes more preserved on intervention side below fibula head ( p = .07) and above fibula head ( p = .10). Christodoulou C., Tsakalos G., Galani E., & Skarlos D. V. (2006). Scalp metastases and scalp cooling for chemotherapy-induced alopecia prevention. Annals of Oncology, 17( 2), 350