Inflammation is a normal immune response to injury, but increasing evidence shows that chronic inflammation could contribute to disease ( 12). Coria-Téllez, A. V., Montalvo-Gónzalez, E., Yahia, E. M., and Obledo-Vázquez, E. N. (2016). Annona muricata: a comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity. Arabian J. Chem. doi: 10.1016/j.arabjc.2016.01.004

Chan WJ, McLachlan AJ, Hanrahan JR, Harnett JE. The safety and tolerability of Annona muricata leaf extract: A systematic review. J Pharm Pharmacol. 2020;72(1):1-16. doi:10.1111/jphp.13182 Qazi AK, Siddiqui JA, Jahan R, et al. Emerging therapeutic potential of graviola and its constituents in cancers. Carcinogenesis. 2018;39(4):522-533. doi:10.1093/carcin/bgy024 Dietitian Alexis Supan, RD, explains what you should know about this trending tropical treat. Soursop nutrition facts And remember that it’s a big fruit with plenty of natural sugars. “One fruit can have 70 or 80 grams of sugar, so you don’t necessarily want to eat an entire fruit at once — especially if you’re concerned about your sugar intake,” notes Supan. In particular, it is a rich source of annonaceous acetogenin compounds (AGEs). Acetogenins inhibit nicotinamide adenine dinucleotide, which is contained in the membranes of cancer cells.However, keep in mind that these are test-tube studies looking at a strong dose of soursop extract. Further studies need to look at how eating the fruit may affect cancer in humans. In one test-tube study, extracts of soursop with varying concentrations were used on different types of bacteria known to cause oral diseases. Keep in mind that there haven’t been any human studies, so it’s too soon to tell if there are any benefits,” Supan says. Possible side effects of soursop Zhang WL, et al. (2013). Chemical and biologicalassessment of Angelica roots from different cultivated regions in a Chineseherbal decoction danggui buxue tang. Furthermore, improved digestion can contribute to overall well-being, as efficient nutrient absorption supports various bodily functions, from energy production to immune response.

Exploring the Leaves of Annona muricata L. as a Source of Potential Anti-inflammatory and Anticancer Agents Bitters is traditionally and most commonly made with alcohol. Alcohol used to make bitters is typically between 40-50 percent ABV. Alcohol helps extract as much as possible from the bittering agents, while also preserving the shelf life of the bitters. Kim GT, Tran NK, Choi EH, et al. Immunomodulatory efficacy of standardized Annona muricata (graviola) leaf extract via activation of mitogen-activated protein kinase pathways in RAW 264.7 macrophages. Evid Based Complement Alternat Med. 2016;2016:2905127. doi:10.1155/2016/2905127 Rady, I., et al. (2018). Anticancer properties of graviola (Annona muricata): A comprehensive mechanistic review.

Functional dyspepsia (FD) is a prolonged feeling of indigestion, discomfort, or fullness in your stomach. Learn more about the condition, its causes… READ MORE These antioxidants combat oxidative stress in the body by neutralizing harmful free radicals, unstable molecules that can damage cells and contribute to chronic diseases such as heart disease and cancer. In fact, in one animal study, soursop extract was found to decrease the levels of certain inflammatory markers involved in arthritis ( 15).