skyn ICELAND Dissolving Microneedle Eye Patches with Hyaluronic Acid & Peptides: to Hydrate, Firm and Smooth Fine Lines (1 Pack)

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Norman,R.E.; Flanagan,J.G.; Rausch,S.M.K.; Sigal,I.A.; Tertinegg,I.; Eilaghi,A.; Portnoy,S.; Sled,J.G.; Ethier,C.R. Exp.EyeRes. 2010, 90, 277–284. doi:10.1016/j.exer.2009.11.001 Chiang, B.; Venugopal, N.; Edelhauser, H. F.; Prausnitz, M. R. Exp. Eye Res. 2016, 153, 101–109. doi:10.1016/j.exer.2016.10.011 Palmitoyl pentapeptide-4 (Matrixyl orPal-KTTKS): increases production of collagen, elastin and glucosaminoglycans, can decrease photoaging and wrinkles Liu,G.-S.; Kong,Y.; Wang,Y.; Luo,Y.; Fan,X.; Xie,X.; Yang,B.-R.; Wu,M.X. Biomaterials 2020, 232, 119740. doi:10.1016/j.biomaterials.2019.119740 Waghule,T.; Singhvi,G.; Dubey,S.K.; Pandey,M.M.; Gupta,G.; Singh,M.; Dua,K. Biomed.Pharmacother. 2019, 109, 1249–1258. doi:10.1016/j.biopha.2018.10.078

In traditional microneedling, needle size is a major factor factor in the treatment’s effectiveness. Most people require needles that are 1.0mm or longer to reach the dermis.

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Debbasch,C.; Ebenhahn,C.; Dami,N.; Pericoi,M.; VandenBerghe,C.; Cottin,M.; Nohynek,G.J. FoodChem.Toxicol. 2005, 43, 155–165. doi:10.1016/j.fct.2004.09.004 Jumelle,C.; Gholizadeh,S.; Annabi,N.; Dana,R. J.ControlledRelease 2020, 321, 1–22. doi:10.1016/j.jconrel.2020.01.057

sufficient mechanical strength to reach 200 µm penetration depth; MNs were much more efficient than traditional suspension For this study, the team tested magnesium microneedles patches on the delicate undereye area that is susceptible to wrinkles. High performing but gentle on skin our ultimate eye patches are formulated to soften fine lines, strengthen skin elasticity, boost hydration, and brighten the eye area. When the needles create microscopic punctures in the skin, it triggers the body’s natural wound healing process, which promotes cell turnover, boosts collagen production and helps to reduce future acne breakouts. The punctures also allow any treatments or serums that have been applied before microneedling (such as vitamin C or hyaluronic acid) to reach the deeper layers of the skin. DiPrima,G.; Licciardi,M.; CarfìPavia,F.; LoMonte,A.I.; Cavallaro,G.; Giammona,G. Int.J.Pharm. 2019, 567, 118459. doi:10.1016/j.ijpharm.2019.118459Collagen: This is usually just a humectant moisturiser, since it can’t get through the stratum corneum, but because of the microneedles this is much less of an issue. Adding broken (hydrolysed) collagen to the skin can stimulate it to produce more collagen, which is how collagen supplements could potentially work. Ingredients: Trehalose, Cellulose Gum, Hydrolyzed Hyaluronic Acid, Glycerin, Sodium Hyaluronate, Aqua, Hydrolyzed Collagen, Butylene Glycol, PEG-60 Hydrogenated Castor Oil, Madecassoside, Adenosine, Acetyl Hexapeptide-8, Copper Tripeptide-1, Palmitoyl Pentapeptide-4, PEG-40 Hydrogenated Castor Oil, PPG-26 Buteth-26, 1,2-Hexanediol, Caprylyl Glycol. How to use dissolving microneedle patches Kang G , Tu TN, Kim Set al., Adenosine‐loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration, Int J Cosmet Sci 2018, 40: 199–206. DOI: 10.1111/ics.12453 Cárcamo-Martínez,Á.; Mallon,B.; Domínguez-Robles,J.; Vora,L.K.; Anjani,Q.K.; Donnelly,R.F. Int.J.Pharm. 2021, 599, 120455. doi:10.1016/j.ijpharm.2021.120455

drug containing tip after optimization was delivered to the mouse cornea and efficiently reduced progression of keratitis Cometto-Muñiz,J.E.; Cain,W.S.; Hudnell,H.K. Percept.Psychophysics 1997, 59, 665–674. doi:10.3758/bf03206014 Verin,P.; Allewaert,R.; Joyaux,J.C.; Piozzi,E.; Koliopoulos,J.; Bloch-Michel,E. Eur.J.Ophthalmol. 2001, 11, 120–125. doi:10.1177/112067210101100203 Palakurthi,N.K.; Correa,Z.M.; Augsburger,J.J.; Banerjee,R.K. J.Ocul.Pharmacol.Ther. 2011, 27, 151–156. doi:10.1089/jop.2010.0037 Koh,K.J.; Liu,Y.; Lim,S.H.; Loh,X.J.; Kang,L.; Lim,C.Y.; Phua,K.K.L. Sci.Rep. 2018, 8, 11842. doi:10.1038/s41598-018-30290-3There are a few different types of microneedles. There are solid steel microneedles, like the type you see in dermarollers and dermastampers, and there are hollow microneedles, which can be used to inject ingredients. Then there’s dissolving microneedles. Hui,A.; Bajgrowicz-Cieslak,M.; Phan,C.-M.; Jones,L. Clin.Ophthalmol. 2017, 11, 1657–1665. doi:10.2147/opth.s141404

I’ve been using Eye Rejuvenator over the last 6 weeks. I love how easy the patches have been to use and incorporate into my routine. You literally peel them off gently push them and you can feel the MicroCrystals working. I can see the improvement the plumping of my lines and my eye area looks more awake and alive.

Peace Out Wrinkles, £25 | Peace Out

This barrier is really useful since it stops water and other essential things inside our bodies from leaking out into the environment, and it also stops toxins and irritants from the environment from leaking in.But when it comes to skincare, it’s not as great – we actually want ingredients to penetrate into our skin to where they can work! Heikal,M.A.; Soliman,T.T.; Abousaif,W.S.; Shebl,A.A. Graefe'sArch.Clin.Exp.Ophthalmol. 2022, 260, 353–361. doi:10.1007/s00417-021-05356-0 Huang,D.; Chen,Y.-S.; Rupenthal,I.D. Adv.DrugDeliveryRev. 2018, 126, 96–112. doi:10.1016/j.addr.2017.09.008 Souto,E.B.; Dias-Ferreira,J.; López-Machado,A.; Ettcheto,M.; Cano,A.; CaminsEspuny,A.; Espina,M.; Garcia,M.L.; Sánchez-López,E. Pharmaceutics 2019, 11, 460. doi:10.3390/pharmaceutics11090460 Grumezescu,A.M. Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology; William Andrew, 2017.