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Both are necessary for producing a sufficient number of red blood cells to carry oxygen around the body. Please note: You should seek medical advice before taking dietary supplements and please remember they are not a substitute for a balanced diet. For females with a vitamin B12 deficiency and levels below 150 mg/dL the risk was five times higher, compared to those with levels above 400 mg/dL ( 7). Interestingly, low blood levels of vitamin B12 have been linked with reduced bone mass, though clinical trials have not definitively supported the efficacy of B vitamin supplements in treating fractures ( 17).
As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Vitamin B12 is a water-soluble vitamin that plays an important role in brain function and red blood cell production. Vitamin B12 plays a key role in many aspects of health and may support bone health, red blood cell formation, energy levels, and mood.
People who eat a varied diet and are generally in good health can obtain the required amount from food. However, current evidence is lacking, and additional high quality studies are needed to determine how vitamin B12 may affect metabolism and body fat in humans. A small clinical study with 10 participants (mean age 81 years) found that the bioavailability of a 1,000 mcg cobalamin dose was 2% with intranasal administration, which is similar to the bioavailability of an oral dose [ 29]. While relatively few younger adults are deficient in B12, up to 20% of adults over the age of 60 have less than optimal blood levels of this nutrient ( 10, 11).
Furthermore, maternal vitamin B12 deficiency may contribute to premature birth or miscarriage ( 4, 5, 6). In these situations, it’s usually recommended that you supplement your diet with either a B12 shot or oral supplement. However, oral contraceptives can reduce the amount of vitamin B12 you absorb from your cyanocobalamin tablets.This formulation appears to be effective in raising vitamin B12 blood levels in adults and children [ 27, 28]. You or the person who's unwell may also have a rash that's swollen, raised, itchy, blistered or peeling. JAMA Internal Medicine: “Association of Processed Meat, Unprocessed Red Meat, Poultry, or Fish Intake with incident Cardiovascular Disease and All-Cause Mortality.
The purpose of the green tea in the spray is not this caffeine element, but that it is a natural preservative as well as being an antioxidant. In a large review, vitamin B12 supplements had no effect on depressive symptoms in the short term but may help prevent relapse over the long term ( 23).
However, there’s currently no evidence that taking B12 supplements increases energy levels in people who are not deficient in this nutrient ( 1). This same serving size also packs a good amount of lean protein, phosphorus, selenium, and vitamins A and B3 ( 19).
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