Gorilla Hitler – A gorilla version of Adolf Hitler and member of the Legion of Hitlers. He is a parody of Gorilla Grodd. Hamurai (voiced by Kevin Michael Richardson) – A samurai that wears armor made of ham, steaks, sausages, and bacon strips. It was mentioned that he went to college with Reverse Giraffe. Alternate David Letterman (voiced by Jeff Bergman) – A version of David Letterman from Dimension C-500A who interviews that dimension's Jerry Smith who talks about Cloud Atlas Along with voicing Summer Smith, Grammer also provides the voice work for other versions of the character. Lady Katana, voiced by Ally Maki, is an Asian cyborg- ninja first mentioned in " Vindicators 3: The Return of Worldender" as having died. After making her official debut in the prequel comic book arc "Vindicators 1", published by Oni Press, the character returned in the animated miniseries Vindicators 2.

Shonda (voiced by Debra Wilson) - A news anchor who works with John on a news channel. She would mostly criticize the actions done by Andre Curtis more than John.Along with voicing Beth Smith, Chalke also provides the voice work for other versions of the character. Oni Press’ Solicitations for December 2017 (English). Comic Book Resource. Retrieved on September 22, 2017. Supernova, Cosmic Heroine, voiced by Gillian Jacobs, is a star-themed superheroine previously married to Alan Rails, having an affair with Million Ants. She is a parody of Starfire, with a design inspired by Singularity. Tag Man (voiced by Justin Roiland) – An enormous and cheerful creature whose name is based on a "tag". He is seen during the post-credits fighting different opponents.

Supernova goes to a nightclub with Calypso, Lady Katana, and Diablo Verde. However, she gets drunk and ends up inadvertently killing the other three Vindicators and the entire nightclub. Alan tries to comfort the emotionally distraught Supernova while Vance murders the bartender to silence him. In 1996, Matt Selman wrote a The Vindicators television pilot script for Comedy Central, revolving around "a team of super heroes with real-life problems". In 1998, the network agreed to produce a pilot from Selman's script, which on completion, was immediately shelved from release due to poor quality, never to be aired. [3] Monogatron Queen (voiced by Kathleen Turner) – The Queen of the Monogatrons and the wife of the Monogatron King. She enjoys podcasts and arguing with her husband. Vance and Supernova slaughter an alien species invading another planet. They then contemplate mercy killing a mortally wounded alien but it dies before they can actually mercy kill it. Supernova then suffers a miscarriage, resulting in an explosion that destroys the planet they just saved. Nevin, Will (January 9, 2016). "That Mr. Poopybutthole –– he's the star: Chatting with the team behind ' Lil' Poopy Superstar '". Oregon Live . Retrieved January 9, 2016.

Jan Michael Vincent – A real-life American actor who, in-universe of an alternate reality, stars in a film called Jan Quadrant Vincent 16. Mrs. Sullivan – A cat lady that is featured in the trailer for "Last Will and Testimeow: Weekend at Dead Cat Lady's House II" (a parody of Weekend at Bernie's), which was written and directed by the Jerry Smith of Dimension C-500A. After she dies, her cats control her body like a puppet to make it look like that she is still alive and can remain on the estate. Along with voicing Jerry Smith, Parnell also provides the voice work for other versions of the character.